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Analgesic activity of 3-alkyl (aryl)-4-(nitrophenylmetheleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones

Krishna Shriramji Pathade, Sandeep Balavant Patil, Manish Sharad Kondawar

Six new3-alkyl (aryl)-4-(arylmetheleneamino)-4, 5-dihydro-1H-1, 2, 4-triazol- 5-oneswere prepared by refluxing 4, 5-dihydro-1H-1, 2, 4-triazol-5-oneswith substituted benzaldehyde. Compounds obtained were characterized and screened for analgesic activity by acetic acid induced writhing. These compounds were found to be active analgesic activity. Compound (3c, 3d and 3f) were shown highly potent analgesic activity.