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An Efficient One Pot Three Component Synthesis of 4-Aryl-6-(3-Coumarinyl) Pyrimidin-2 (1h)-Ones Under Solvent Free Conditions

B. Prasanna, K. Praveen Kumar, N. Rakesh and Y. Prashanthi

Silica gel supported zirconyl chloride octahydrate was found to be an efficient and recyclable catalyst for the synthesis of a series of biologically important molecules in high turnover numbers and rates. Substituted 4-aryl-6-(3-coumarinyl) pyrimidin-2 (1H)-ones can be prepared in high yield and purity by direct reaction via., cyclocondensation of urea and 3-acetylcoumarin with substituted aldehydes in the presence of a catalytic amount of ZrOCl2.8H2O/SiO2 as Lewis acid and at ambient temperature under solvent-free conditions. The synthesized compounds 4(a-e) were characterized by IR, NMR and Mass spectral analysis.