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A Facile Synthesis of New Heterocyclic Compounds from Thiourea and Urea, which Links with Some Hexoses

Amira A Ghoneim and Nesrin Morsy

Background: Thiourea was considered as an important compound which produced industrial chemical products, and synthesis of heterocyclic compounds. Urea and thiourea derivatives were an important in purification factors for organic and inorganic wastes. The research methodology deals with three component cycloaddition phenols and urea with benzaldehyde in the presence of absolute ethanol at 80°C for 8 h, under reflux after compellation reaction the product linkage with some sugar. A series of new thiourea and urea derivatives have synthesized by the reaction of multicomponent such as phenol, benzaldehyde and urea or thiourea to yield a new amides derivatives 4a, 4b and 6a, 6b respectively. The amide compounds have condensed with a different monosaccharide sugars like (D-glucose, D-galactose, and D-fructose) afforded new N-glucoside compounds