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A convenient one-pot three component synthesis of 1,4-dihydropyridines using basic alumina as a catalyst in aqueous media under microwave irradiation

Mantu Rajbangshi, Badaker M.Laloo, Bekington Myrboh

A simple and convenient one-pot multi-component reaction has been described for the synthesis of 1,4-dihydropyridines from substituted benzaldehydes, â-keto esters and ammonium acetate catalyzed by basic alumina (10 mol%) in aqueousmediumundermicrowave irradiation in good yields. The recyclability of basic alumina as a catalyst has been demonstrated and a comparative study between basic, acidic and neutral alumina is made. The generality and functional tolerance of this convergent and environmentally benign method is presented.