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A comparative study on the antidiabetic effects of Trigonella foenum graecum and Caesalpinia bonducella in alloxan induced diabetic rats.

Thirunethiran Karpagam, B.Varalakshmi, George Margret Rosaland Fathima Mary

Diabetes mellitus is a metabolic disease characterized by defects in insulin secretion. Allopathic medicines decrease the glucose level by acting on pancreatic beta cells. Indigenous medicines are used to treat diabetes mellitus because, the side effect are less, easy availability and less expensiveness. Trigonella foenum graecum seeds and Caesalpinia bonducella can increase glucose induced insulin release in human and rat pancreatic islets. The studywas carried out to compare the antidiabetic potential of Trigonella foenum graecum seeds and Caesalpinia bonducella in alloxan induced diabetic rats. In our present study group I rats were treated with saline, group II rats with alloxan, group III rats with methanolic extract of Caesalpinia bonducella leaves along with alloxan and group IV rats with Trigonella foenum graecum seeds powder along with alloxan and group V ratswithGlibenclamide alongwith alloxan for 21 days. The objective of the study was to analyze the diabetic profile, lipid profile, toxicity studies, changes in the levels of Homocysteine, (marker of cardiovascular disease), Folic acid (enhancer of endothelial function) and to compare the antidiabetic effects of Trigonella foenum graecum and Caesalpinia bonducella in alloxan induced diabetic rats.