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1,3-Bis (4-chlorophenyl)-2, 3-epoxypropanone as synthons in synthesis of some interesting potential antimicrobial agents

Aymn E.Rashad, Ahmed H.Shamroukh,Maher A.El-Hashash, Ahmed F.El-Farargy, Nabil M.Yousif, Mowafia A.Salama, Nayera A.M.Abdelwahed, Mahmoud El-Shahat

Thiswork presents a systematic and comprehensive survey on the chemical reactivity of 1,3-Bis (4-chlorophenyl)-2,3-epoxypropanone. This compound is important intermediates for the synthesis of a variety of otherwise difficult to obtain synthetically useful and novel cyclic systems (2-12). The structure of the prepared products was elucidated by elemental and spectroscopic data. Moreover, the antimicrobial activity of prepared compounds has also been assessed and compound (11) revealed activity compared to the activity of the commonly used antimicrobial drug.